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Clinical picture: NHL (Non Hodgkin Lymphoma)

Trial: HOVON 900 DLBCL screening

1. Overview
Study details
2. Patient eligibility criteria
3. Registration (& randomization) of patients
4. Participating parties
5. Participating sites
6. Instruction videos
7. Download documentation / forms

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HOVON 900 DLBCL status


The HOVON 900 DLBCL study is now closed for inclusion.


1. Overview


Patients over 18 years with DLBCL (according to WHO 2016 classification) with a proven MYC rearrangement as detected by FISH, are high risk patients and have a very poor prognosis on standard first line therapy with R-CHOP immune-chemotherapy. To identify MYC rearranged DLBCL patients, all DLBCL patients will (after informed consent) be registered in this screening-database (HOVON 900). Subsequently, MYC FISH testing will be performed and patients with a proven MYC rearrangement will be considered for other treatment than R-CHOP (either according to an open trial or according to the HOVON Lymphoma Working Group guidelines in case no trials are open or in case the patient is not eligible). All patients (treated in trials as well as patients treated outside trials) will be included in a virtual tissue bank (HOVON Pathology Facility and Biobank (HOP)) for future tissue-based MYC-related studies and for epidemiological studies.

All logistics will be performed by the HOVON Pathology Facility and Biobank (HOP,





Study details

Type of monitoring for this study


Target number of patients


Current number of patients


Study objectives

The primary objective is to effectively identify patients who may be eligible for the HOVON130 trial, to collect anonymized data of all DLBCL and BCL-U patients (MYC positive and negative) for epidemiological studies and to install a virtual tissue bank for future comparative MYC-related biological research.

2. Patient eligibility criteria

Inclusion criteria

♦ All patients diagnosed with newly diagnosed DLBCL according to WHO 2016. (patients with transformed follicular lymphoma are not eligible)
♦ Age ≥ 18 years
♦ Within 8 weeks after the diagnosis of DLBCL

3. Registration (& randomization) of patients


Eligible patients should be registered. Patients need to be registered at the HOVON Data Center by one of the following options:
Trial Online Process (TOP, A logon to TOP can be requested at the HOVON Data Center for participants.
By faxing the completed registration/randomization CRF +31.10.7041028 Monday through Friday, from 09:00 to 17:00 CET
By phone +31.10.7041560 Monday through Friday, from 09:00 to 17:00 CET

Registration criteria

The following information will be requested:

• Protocol number
• Institution name
• Name of caller/responsible investigator
• Local patient code (optional)
• Sex
• Date of birth (or partial date of birth if date of birth not allowed, e.g.01/01/YOB)
• Date written informed consent
• Specific items for which this patient gives consent (see ICF)
• Date of diagnosis
• Diagnosis (DLBCL or BCL-U)
• Name of the local pathology laboratory
• Local pathology registration number

4. Participating parties

Principal Investigator(s)

Dr. M. Chamuleau (VUMC)

Central Data Manager(s)

Dhr. Drs. R. Sewsaran (Erasmus MC - Daniel)

Other functions

Reviewer - Pathology - HOP pathologist (VUMC)
Reviewer - Pathology - Mw. Dr. D. de Jong (VUMC)
Reviewer - Pathology - Dr. M. Nijland (UMCG)

Trial manager

H. Zanders ( )

Other functions

Please contact monitors at

5. Participating sites

Included patients *
NL-Alkmaar-Noordwest Ziekenhuisgroep
NL-Almelo-Ziekenhuisgroep Twente, loc. Almelo
NL-Amersfoort-Meander MC
NL-Amsterdam-Antoni van Leeuwenhoek ZH
NL-Amsterdam-Sint Lucas Andreas ZH, Lucas
NL-Apeldoorn-Gelre ziekenhuizen, Apeldoorn
NL-Assen-Wilhelmina Ziekenhuis
NL-Beverwijk-Rode Kruis Ziekenhuis
Show 54 more...
* Please note that if TOP is not used to register patients for a study, the number of patients shown is zero.

6. Instruction videos

7. Download documentation / forms


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